"(Get Your Kicks on) Route 66" is a popular rhythm and blues standard, composed in 1946 by American songwriter Bobby Troup. The song uses a twelve-bar blues arrangement and the lyrics follow the path of U.S. Route 66 (US 66), which traversed the western two-thirds of the U.S. from Chicago, Illinois, to Los Angeles, California.

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Nat King Cole, as the King Cole Trio, first recorded the song the same year and it became a hit, appearing on Billboard magazine's R&B and pop charts.

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Another version to reach the Billboard charts was that recorded by Bing Crosby with the Andrews Sisters on May 11, 1946 and this reached the No. 14 position in 1946. The song was subsequently recorded by many artists including Chuck Berry, the Rolling Stones, Them, Dr. Feelgood, Asleep at the Wheel, the Manhattan Transfer, Depeche Mode, The Brian Setzer Orchestra, Pappo, The Cramps, John Mayer, George Benson and Peter Tork & Blue Suede Shoes.